Different Arrangement of Dopamine Receptors/NMDA Receptors Heterocomplexes in the Brain Regions of a Healthy Male, Female and Audiogenic Seizure-Prone Male Rats

Differences in the composition and subcellular localization of heteroreceptors brain can trigger central nervous system diseases, including epilepsy autism. Protein-protein interactions between Dopamine Receptors (DRs) GLUN2A GLUN2B subunits are critical mechanisms that regulate dopamine glutamate coordinated signals. These may be involved pathophysiological predisposition epilepsy. We hypothesized specificity dopaminergic neurotransmission audiogenic Seizure-Prone (SP) rats could underlined by distribution expression N-Methyl-D-Aspartate Glutamate Receptor (NMDAR) (NMDAR/DR) heterocomplex. determined oligomerization synaptic extra-synaptic NMDAR with D1 D2 receptors prefrontal cortex Nucleus Accumbens (NAc) healthy epileptic males rats. Considering comorbidity autism is more prevalent females, we also studied pattern interaction. NMDAR/DR heterocomplex formation female The association type 1 (D1R) receptor, fraction epilepsy-prone rats, was lower than male In contrast, interaction D1R receptor higher membranes Furthermore, found D2R/GLUN2B ratio NAc SP Therefore, suggest different subunit proportions male, female, attributed to their cognitive or emotional flexibility.